October 12, 2017

Scientific Board publications

Year Title
2019 Solid-state fluorescence of two zinc coordination polymers from bulky dicyano-phenylenevinylene and bis-azobenzene cores
2019 Novel dicyano-phenylenevinylene fluorophores for low-doped layers: A highly emissive material for red OLEDs
2019 An amphiphilic pyridinoyl-hydrazone probe for colorimetric and fluorescence pH sensing
2019 Fluorescence pH-dependent sensing of Zn(II)by a tripodal ligand. A comparative X-ray and DFT study
2019 Plausible emergence of autocatalytic cycles under prebiotic conditions
2019 The effect of bulky substituents on two π-conjugated mesogenic fluorophores. Their organic polymers and zinc-bridged luminescent networks
2019 Membrane lipid composition: Effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues
2019 The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt
2019 Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity
2019 The opposing contribution of SMS1 and SMS2 to glioma progression and their value in the therapeutic response to 2OHOA
2018 Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology
2018 Data on a real-time tripodal colorimetric/fluorescence sensor for multiple target metal ions
2018 A real-time tripodal colorimetric/fluorescence sensor for multiple target metal ions
2018 Photophysical Properties of Luminescent Zinc(II)‒Pyridinyloxadiazole Complexes and their Glassy Self-Assembly Networks
2018 Transmembrane peptides as sensors of the membrane physical state
2018 Molecular Dynamics and Morphing Protocols for High Accuracy Molecular Docking
2018 Fragment based molecular dynamics for drug design
2018 Dissipative Particle Dynamics Study of Alginate/Gelatin Aerogels Obtained by Supercritical Drying
2018 AIE/ACQ effects in two DR/NIR emitters: A structural and DFT comparative analysis
2018 Solid-state highly efficient dr mono and poly-dicyano-phenylenevinylene fluorophores
2018 Guaiacol as a drug candidate for treating adult polyglucosan body disease
2017 Synthesis, spectroscopic properties and DFT calculations of a novel multipolar azo dye and its zinc(II) complex
2017 A novel fluorescent solvatochromic probe for lipid bilayers
2017 Computational study on human sphingomyelin synthase 1 (hSMS1)
2017 G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions
2017 Synthesis and antimicrobial studies of new antibacterial azo-compounds active against staphylococcus aureus and listeria monocytogenes
2017 From cadmium(II)-aroylhydrazone complexes to metallopolymers with enhanced photoluminescence. A structural and DFT study
2017 Structure modification of an active azo-compound as a route to new antimicrobial compounds
2017 Mapreduce in computational biology – A synopsis
2017 On-off mechano-responsive switching of ESIPT luminescence in polymorphic n-salicylidene-4-amino-2-methylbenzotriazole
2017 Oxadiazole-carbazole polymer (POC)-Ir(ppy)3 tunable emitting composites
2017 Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation
2017 Membrane-lipid therapy: A historical perspective of membrane-targeted therapies — From lipid bilayer structure to the pathophysiological regulation of cells
2017 Role of the C-terminal basic amino acids and the lipid anchor of the Gγ2 protein in membrane interactions and cell localization
2017 The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer’s disease, improving behavioral motor function and survival
2017 Membrane-lipid therapy: A historical perspective of membrane-targeted therapies-From lipid bilayer structure to the pathophysiological regulation of cells
2017 Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: Implications for therapy
2017 Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion
2016 Yada: a novel tool for molecular docking calculations
2016 Antimicrobial azobenzene compounds and their potential use in biomaterials
2016 Mono-, Di-, and Polymeric Pyridinoylhydrazone ZnII Complexes: Structure and Photoluminescent Properties
2016 Models for the prediction of antimicrobial peptides activity
2016 A new flexible protocol for docking studies
2016 Novel algorithm for efficient distribution of molecular docking calculations
2016 Oxadiazole Based Polyether as Sensitive Films for Ratiometric Optical Temperature Detection
2016 Interpenetration of natural polymer aerogels by supercritical drying
2016 The central role of heat shock factor 1 in synaptic fidelity and memory consolidation
2016 The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
2016 7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome
2016 Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe
2016 Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila
2016 Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer’s Disease
2016 Identification of Biomarkers of Necrosis in Xenografts Using Imaging Mass Spectrometry
2016 Optimized Protocol to Analyze Changes in the Lipidome of Xenografts after Treatment with 2-Hydroxyoleic Acid
2015 Biodegradable antimicrobial films based on poly(lactic acid) matrices and active azo compounds
2015 Complete glutaraldehyde elimination during chitosan hydrogel drying by SC-CO2 processing
2015 Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis
2015 Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: Effects of oxidized low-density lipoprotein treatment
2015 Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells
2015 Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment
2015 G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization
2015 The novel anticancer drug hydroxytriolein inhibits lung cancer cell proliferation via a protein Kinase Cα- And extracellular signal-regulated kinase 1/2-Dependent Mechanisms
2015 Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design
2015 The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease
2015 Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury
2015 Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD
2014 Zn-complex based on oxadiazole/carbazole structure: Synthesis, optical and electric properties
2014 Structural features of the C8 antiviral peptide in a membrane-mimicking environment
2014 The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes
2014 Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets
2014 Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications
2014 Electrical hole transport properties of an ambipolar organic compound with Zn-Atoms on a crystalline silicon heterostructure
2014 Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies
2014 Rac1 participates in thermally induced alterations of the cytoskeleton, cell morphology and lipid rafts, and regulates the expression of heat shock proteins in B16F10 melanoma cells
2014 Alcohol stress, membranes, and chaperones
2014 The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes
2014 Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer
2014 The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health
2014 Regulation of the cancer cell membrane lipid composition by NaCHOleate: Effects on cell signaling and therapeutical relevance in glioma
2014 Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF
2014 Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer’s disease
2014 Description of extreme longevity in the Balearic Islands: Exploring a potential Blue Zone in Menorca, Spain
2013 Optical properties of ionic liquid passivated CdSe/ZnS quantum dots dispersed in POC copolymer
2013 Novel antimicrobial polymer films active against bacteria and fungi
2013 2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug
2013 Small azobenzene derivatives active against bacteria and fungi
2013 Hydroximic acid derivatives: Pleiotropic Hsp co-inducers restoring homeostasis and robustness
2013 White light-emitting nanocomposites based on an oxadiazole-carbazole copolymer (POC) and InP/ZnS quantum dots
2013 Synergetic insulin sensitizing effect of rimonabant and BGP-15 in zucker-obes rats
2013 Key role of lipids in heat stress management
2013 Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma
2013 Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes
2013 Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment
2013 Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
2013 The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid
2013 Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells
2012 Antimicrobial polymer films for food packaging
2012 YADAMP: Yet another database of antimicrobial peptides
2012 Nanocomposites of POC and quantum dots
2012 Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture
2012 A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics
2012 Glycerophospholipid profile in oncogene-induced senescence
2012 Heat shock response in photosynthetic organisms: Membrane and lipid connections
2012 The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics
2012 Insulin resistance occurs in parallel with sensory neuropathy in streptozotocin-induced diabetes in rats: Differential response to early vs late insulin supplementation
2012 2-Hydroxyoleic Acid Induces ER Stress and Autophagy in Various Human Glioma Cell Lines
2012 2-Hydroxyoleate, anontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy
2012 Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells
2011 Membrane-lipid therapy in operation: The HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts
2011 Segregation into domains observed in liquid crystal phases: Comparison of experimental and theoretical data
2011 Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells
2011 The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans
2011 Docosahexaenoic acid reduces amyloid β production via multiple pleiotropic mechanisms
2011 Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody
2011 Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
2010 Design of novel polymeric materials by controlled self-assembly
2010 Synthesis and characterization of new photoluminescent oxadiazole/carbazole containing polymers
2010 Synthesis and characterization of new photoluminescent oxadiazole/ carbazole-containing polymers
2010 Electronic memory effect in a crystalline silicon/polyether heterostructure
2010 Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane
2010 Membrane lipid composition affects plant heat sensing and modulates Ca2+-dependent heat shock response
2010 Live cell segmentation in fluorescence microscopy via graph cut
2010 Xenohormesis: Health benefits from an eon of plant stress response evolution
2010 Neuroprotective effect of small heat shock protein, Hsp27, after acute and chronic alcohol administration
2010 Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line
2010 Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(-)
2010 Genetic modification of the Salmonella membrane physical state alters the pattern of heat shock response
2010 Changes in membrane fluid state and heat shock response cause attenuation of virulence
2010 Interactions of fatty acids with phosphatidylethanolamine membranes: X-ray diffraction and molecular dynamics studies
2010 Minerval induces apoptosis in Jurkat and other cancer cells
2009 Computer simulations of natural and synthetic polymers in confined systems
2009 DPD simulations of PMMA-oleic acid mixture behaviour in organic capped nanoparticle based polymer nanocomposite
2009 Organic memory device with large conductance switching based on oxadiazole – Containing polyether thin films
2009 Photocurrent spectroscopy of UV-photodiodes with an active layer consisting of small molecules that combine oxadiazole and carbazole groups
2009 The role of lipopolysaccharide moieties in macrophage response to Escherichia coli
2009 Interaction of transmembrane-spanning segments of the α2-adrenergic receptor with model membranes
2009 Ternary copper(II) complexes with hippurate derivatives and 1,10-phenanthroline: Synthesis and biological activity
2009 Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid
2008 DDFT simulations of the assembly of block copolymers in confined systems
2008 Investigation of morphology of nanocrystal based nanocomposites. Theoretical and computational analysis
2008 Antioxidant activity of diphenylpropionamide derivatives: Synthesis, biological evaluation and computational analysis
2008 Switching device based on a thin film of an Azo-containing polymer for application in memory cells
2008 A mutant small heat shock protein with increased thylakoid association provides an elevated resistance against UV-B damage in synechocystis 6803
2008 Membrane-associated stress proteins: More than simply chaperones
2008 Membranes: A meeting point for lipids, proteins and therapies: Translational Medicine
2008 HSP72 protects against obesity-induced insulin resistance
2008 Regulation of desaturase gene expression, changes in membrane lipid composition and freezing tolerance in potato plants
2008 Oleic acid content is responsible for the reduction in blood pressure induced by olive oil
2008 Membrane interactions of G proteins and other related proteins
2008 2-Hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner
2008 Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats
2008 Effects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membranes
2007 Membrane-regulated stress response: A theoretical and practical approach
2007 New catalyst for the synthesis of poly(butylene terephthalate) with high thermo-oxidative stability
2007 Can the stress protein response be controlled by ‘membrane-lipid therapy’?
2007 Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line
2007 The small heat shock proteins and their clients
2007 Membrane regulation of the stress response from prokaryotic models to mammalian cells
2007 Lipid-protein interactions in GPCR-associated signaling
2007 G protein-coupled receptor systems and their lipid environment in health disorders during aging
2007 Synthesis and mass spectroscopy kinetics of a novel ternary copper(II) complex with cytotoxic activity against cancer cells
2007 Consumption of virgin olive oil influences membrane lipid composition and regulates intracellular signaling in elderly adults with type 2 diabetes mellitus
2007 Interaction of the C-terminal region of the Gγ protein with model membranes
2007 Mutations in TBX1 genocopy the 22q11.2 deletion and duplication syndromes: A new susceptibility factor for mental retardation
2007 Reduced expression of the sarcoplasmic calcium pump SERCA2 in skeletal muscle from patients with chronic obstructive pulmonary disease and low body weight Disminución de la expresión de la bomba de calcio sarcoplásmica (SERCA2) en el músculo esquelético de pacientes con EPOC y bajo peso corporal
2006 Stochastic simulations of homogeneous chemically reacting systems
2006 Synthesis and characterization of new electroluminescent molecules containing carbazole and oxadiazole units
2006 Monitoring of the initial degradation of oxadiazole based blue OLED’s
2006 Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
2006 Membrane-lipid therapy: A new approach in molecular medicine
2005 Segregation and phase transition in mixed lipid films
2005 The significance of lipid composition for membrane activity: New concepts and ways of assessing function
2005 CURVIS: A program to study and analyse crystallographic structures and phase transitions
2005 Blue emitting OLED with oxadiazole/carbazole containing active layer
2005 The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response
2005 Heat shock proteins as emerging therapeutic targets
2005 Native folding of aggregation-prone recombinant proteins in Escherichia coli by osmolytes, plasmid- or benzyl alcohol-overexpressed molecular chaperones
2005 Heat shock lipid in cyanobacteria during heat/light-acclimation
2005 Membrane fluidization triggers membrane remodeling which affects the thermotolerance in Escherichia coli
2005 The repression of E2F-1 is critical for the activity of minerval against cancer
2005 Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes
2005 Influence of the membrane lipid structure on signal processing via G protein-coupled receptors
2005 Membrane structure modulation, protein kinase Cα activation, and anticancer activity of minerval
2005 IFN-γ prevents TNF-α-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-κB activity